abstract：BACKGROUND:Combination therapy consisting of a platinum agent, 5-fluorouracil and cetuximab (EXTREME regimen) is recommended for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M-SCCHN). However, it is advisable to use platinum-free regimens as first-line therapy in patients resistant to platinu...

journal_title：Acta oto-laryngologica

authors： Sato H,Tsukahara K,Okamoto I,Katsube Y,Shimizu A,Kondo T,Hanyu K,Fushimi C,Okada T,Miura K

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The prognostic factors of facial paralysis complicated by middle ear cholesteatoma (MEC) are largely unknown due to limited reports and smaller sample size. OBJECTIVES:This study aimed to analyze prognostic factors of postoperative outcomes of facial paralysis complicated by MEC. MATERIAL AND METHODS:Clini...

journal_title：Acta oto-laryngologica

authors： Li Q,Jia Y,Feng Q,Tang B,Luo X,Xu P,Wang D,Zhang X

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Laryngeal squamous cell carcinoma (LSCC) is rare in the young. OBJECTIVES:We characterized the clinical behavior of LSCC and assessed the presentation of second primary tumors (SPCs) in this patient population. MATERIALS AND METHODS:Data from the Finnish Cancer Registry (FCR) were used to identify an epide...

journal_title：Acta oto-laryngologica

authors： Silén S,Haapaniemi A,Dickinson A,Rönn K,Mäkitie A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Supracricoid partial laryngectomy (SCL) can have a positive impact on patients' quality of life by circumventing dysphagia and voice problems resulting from creation of a permanent stoma after conventional total laryngectomy (TL) surgery. AIMS/OBJECTIVES:The aim of this study was to investigate the oncologi...

journal_title：Acta oto-laryngologica

authors： Kim JH,Kim WS,Koh YW,Kim SH,Byeon HK,Choi EC

更新日期：2018-12-01 00:00:00

abstract：:Background： Atoh1, also named Math1, is essential for the development of inner ear hair cells. Many studies have confirmed that the absence of Atoh1 resulted in a total loss of inner ear hair cells, which indicates that Atoh1 plays very similar roles in the development of hair cells in the cochlea and vestibule. Objec...

journal_title：Acta oto-laryngologica

authors： Zhang Y,Tang Q,Xue R,Gao J,Yang H,Gao Z,Lin G

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Oropharyngeal squamous cell carcinoma (OPSCC) positive for human papillomavirus (HPV) increases wolrd wide. AIMS/OBJECTIVES:The objective for this study has been to evaluate tumor phenotypes and tumor host responses with respect to five-year disease-specific survival (DSS) in HPV(+) and HPV(-) patients. MA...

journal_title：Acta oto-laryngologica

authors： Haave H,Gulati S,Brekke J,Lybak S,Vintermyr OK,Aarstad HJ

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Efficacy of current treatment methods in idiopathic sudden sensorineural hearing loss (ISSNHL) is still unsatisfactory. OBJECTIVE:This study aimed to discover in differences in effect between steroid applications responsible for promoting the prognosis in ISSNHL. MATERIALS AND METHODS:A study was conducted...

journal_title：Acta oto-laryngologica

authors： Jiang K,Li S,Cheng L,Yang J

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Endolymphatic sac decompression has shown limited success for the treatment of Ménière's disease (MD). We have published a novel technique with very promising results for the treatment of refractory MD: the Endolymphatic Duct Blockage (EDB) with two titanium clips. One of the challenges of this technique was...

journal_title：Acta oto-laryngologica

authors： Saliba I,Asmar MH

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:To identify the difference of surgical margin and recurrence status of early stage tongue carcinoma via wide excision in a single institution with and without free flap reconstruction. OBJECTIVE:Survey whether the reconstruction methods for early tongue cancer affects disease control, survival outcomes. ME...

journal_title：Acta oto-laryngologica

authors： Lu CC,Tsou YA,Hua CH,Tsai MH

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Li quick repositioning maneuver for treatment of geotropic horizontal canal benign paroxysmal positional vertigo (HC-BPPV) was reported in the literature. OBJECTIVE:The aim of this study is to observe the clinical efficacy of the Li quick repositioning maneuver for the treatment of geotropic HC-BPPV. METHO...

journal_title：Acta oto-laryngologica

authors： Li J,Zou S,Tian S

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To analyze the outcomes following re-irradiation for local recurrence of rare head and neck tumors. MATERIAL AND METHODS:We retrospectively analyzed 11 patients who had received intensity-modulated radiation therapy (IMRT) for recurrent tumors in the head and neck except for laryngopharynx. RESULTS:Primary tu...

journal_title：Acta oto-laryngologica

authors： Doi H,Uemoto K,Masai N,Tatsumi D,Shiomi H,Oh RJ

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the capability of indirect computed tomography and magnetic resonance lymphography (CT/MR-LG) with gadolinium-loaded, polyethylenimine-entrapped gold nanoprobes (Gd-Au PENPs) for assessing lingual sentinel lymph node (SLN) metastasis in a tongue VX2 carcinoma model. MATERIALS AND METHODS:Seventee...

journal_title：Acta oto-laryngologica

authors： Yang Y,Zhou B,Zhou J,Shi X,Sha Y,Wu H

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:The association between type 2 diabetes mellitus (T2DM) and hearing loss has not been fully investigated and there is little information on the effects of pre-diabetes on alterations in auditory function in Chinese subjects. METHODS:The study recruited 51 patients with T2DM, 55 patients with pre-diabetes an...

journal_title：Acta oto-laryngologica

authors： Li J,Zhang Y,Fu X,Bi J,Li Y,Liu B,Zhang L

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease. Eosinophilic CRSwNP (ENP) exhibits a strong tendency for recurrence after surgery. Given that the treatment strategy of ENP differs from that of non-eosinophilic CRSwNP (nENP), clinical diagnostic criteria that distinguish ENP from...

journal_title：Acta oto-laryngologica

authors： Xu M,Zhang W,Chen D,Zhou H,Chen L

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinical value of pulse oximetry watch (POW) for diagnosing pediatric Obstructive sleep apnea/hypopnea syndrome (OSAHS). METHODS:We selected 32 children (boys: 25, 4-16 years old) who came to the hospital for diagnosing OSAHS from July to October 2016. Polysomnography (PSG) and POW were used ...

journal_title：Acta oto-laryngologica

authors： Ma JR,Huang JJ,Chen Q,Wu HT,Xiao KL,Zhang YT

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:CD73 is an enzyme crucial in the metabolism of immunosuppressive adenosine. In cancer, it has various functions including tumor growth and metastases. Squamous cell carcinoma of the head and neck has an overall poor prognosis, also due to early spread of metastatic cells. MATERIALS AND METHODS:Tumor and l...

journal_title：Acta oto-laryngologica

authors： Mandapathil M,Boduc M,Netzer C,Güldner C,Roessler M,Wallicek-Dworschak U,Jahns E,Stuck B

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:A meta-analysis was conducted to compare oncologic outcomes for patients of T1a glottic carcinoma who were treated with laser surgery (LS) or radiotherapy (RT). METHODS:All related studies published up to October 2016 were acquired by searching PubMed, EMBASE, and Cochrane were conducted by two authors, wit...

journal_title：Acta oto-laryngologica

authors： Huang G,Luo M,Zhang J,Liu H

更新日期：2017-11-01 00:00:00

abstract：CONCLUSIONS:The critical stage for cochlear gene regulation in the embryo is E49-E56. These data provide a valuable resource to help elucidate gene regulation in cochlear development and will benefit ear-related studies, especially those that focus on gene and stem cell therapies in hearing loss. OBJECTIVES:To investi...

journal_title：Acta oto-laryngologica

authors： Wang Q,Zhang Y,Guo W,Liu Y,Wei H,Yang S

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:We used ocular vestibular evoked myogenic potentials to investigate the relationship between residual dizziness and utricular function following the canalith repositioning procedure for benign paroxysmal positional vertigo. METHODS:Ocular vestibular evoked myogenic potentials were measured in 44 patients (40...

journal_title：Acta oto-laryngologica

authors： Seo T,Shiraishi K,Kobayashi T,Mutsukazu K,Fujita T,Saito K,Watanabe H,Doi K

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:To investigate the outcome of pediatric tracheostomy and identify predictive factors for successful decannulation. METHODS:We performed a retrospective chart review of a series of 42 consecutive patients of less than 24 months of age who underwent a tracheostomy between 2012 and 2015. RESULTS:Successful de...

journal_title：Acta oto-laryngologica

authors： Takahashi N,Takano K,Mitsuzawa H,Kurose M,Himi T

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The balloon catheter has been used for a decade to dilate paranasal sinus outflow tracts. The question is: how wide and how durable is the dilation of drainage pathways in patients in long-term observations after this procedure? OBJECTIVE:The objective of our study was to observe the changes occurring in th...

journal_title：Acta oto-laryngologica

authors： Szczygielski K,Galusza B,Rapiejko P,Klopotek M,Jurkiewicz D

更新日期：2017-09-01 00:00:00

abstract：HYPOTHESIS:To examine the cellular events following induced superficial lesions of the human tympanic membrane (TM). Such information could lead to enhanced appreciation of repair mechanisms and novel strategies to restore TM perforations. BACKGROUND:Persistent perforation of the TM in chronic otitis media is a major ...

journal_title：Acta oto-laryngologica

authors： Schart-Morén N,Mannström P,Rask-Andersen H,von Unge M

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether the extent of expression of hyaluronan (HA) and epidermal growth factor receptor (EGFR) in squamous cell carcinoma of the mobile tongue can predict the risk of cervical metastasis and survival. STUDY DESIGN:Retrospective histopathologic study. METHODS:Surgical specimens from 64 patien...

journal_title：Acta oto-laryngologica

authors： Lindell Jonsson E,Nylander K,Hallén L,Laurell G

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:To assess the relationships between CD163 expression, localization of CD163+ macrophages, clinicopathological features and prognosis of NPC. METHODS:A total of 110 cases of NPC specimens and 80 cases of nasopharyngitis specimens were analysed for CD163 expression by immunohistochemistry and EBERs expression...

journal_title：Acta oto-laryngologica

authors： Huang H,Liu X,Zhao F,Lu J,Zhang B,Peng X,Zhang M,Chen X,Li G,Li X

更新日期：2017-08-01 00:00:00

abstract：CONCLUSIONS:The heparin-binding epidermal growth factor-like growth factor (HB-EGF) plays an essential role in the development and invasiveness of cholesteatoma. This study may help to realize the molecular mechanisms underlying the pathogenesis of cholesteatoma and make HB-EGF a promising target for drug intervention ...

journal_title：Acta oto-laryngologica

authors： Xie S,Wang X,Ren H,Liu X,Ren J,Liu W

更新日期：2017-08-01 00:00:00

abstract：CONCLUSION:The endoscopic transnasal approach with IGS is a safe and effective technique, allowing completely resection of JPOF, with minimal morbidity and recurrence. OBJECTIVES:JPOF is a benign but locally aggressive fibro-osseous lesion. This study presents a series of JPOF cases, involving anterior skull base and ...

journal_title：Acta oto-laryngologica

authors： Wang M,Zhou B,Cui S,Li Y

更新日期：2017-07-01 00:00:00

abstract：CONCLUSIONS:Intratympanic steroid (ITS) treatment groups exhibited better outcomes in PTA improvement and recovery rate than systemic steroid therapy (SST) groups. Whether initial hearing loss severity would influence the PTA improvement and recovery rate still requires further research. OBJECTIVE:This article was aim...

journal_title：Acta oto-laryngologica

authors： Qiang Q,Wu X,Yang T,Yang C,Sun H

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:This study showed that short and long interval treatments achieved comparable success rates. There was no statistically significant difference in the rate of early and late recurrences between the two groups. Modified Epley maneuver can be applied in a short interval time with comparable success and recurr...

journal_title：Acta oto-laryngologica

authors： Kahraman SS,Yildirim YS,Tugrul S,Ozturan O

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The most crucial clinical problem of Eosinophilic Otitis Media (EOM) is sensorineural hearing loss. A previous report revealed that repeated antigen stimulation of middle ear causes eosinophilic inflammation not only in the middle ear but also in the inner ear. OBJECTIVE:The purpose of the present study was...

journal_title：Acta oto-laryngologica

authors： Kudo N,Matsubara A,Nishizawa H,Miura T

更新日期：2017-05-01 00:00:00

abstract：CONCLUSION:Alterations within a novel putative Exon 1a within the gap junction beta 2 (GJB2) gene may play a role in the development of genetic hearing impairment in Austria. OBJECTIVES:Mutations in the GJB2 gene are the most common cause of hereditary sensorineural deafness. Genome-wide screening for alternative tran...

journal_title：Acta oto-laryngologica

authors： Parzefall T,Lucas T,Koenighofer M,Ramsebner R,Frohne A,Czeiger S,Baumgartner WD,Schoefer C,Gstoettner W,Frei K

更新日期：2017-04-01 00:00:00

abstract：CONCLUSION:Each of eight patients with bilateral microtia and atresia underwent bilateral reconstruction of the auricles and external auditory canals and were fitted bilateral canal-type hearing aids in the operated ears to replace a bone conduction hearing aid. The ability to discriminate inter-aural intensity differe...

journal_title：Acta oto-laryngologica

authors： Kaga K,Asato H

更新日期：2017-04-01 00:00:00

abstract：CONCLUSION:Low-dose administration of Aspartame (Ap) did not produce a significant ototoxic effect at the end of the 6th month. However, duration of the ototoxic effect is shortened and severity of the effect is increased as dose and duration of Ap administration is increased. OBJECTIVES:While Ap toxicity has been stu...

journal_title：Acta oto-laryngologica

authors： Ozturan O,Dogan R,Tugrul S,Gedik O,Sjostrand AP,Yildirim YS

更新日期：2017-04-01 00:00:00

abstract：CONCLUSION:Intra-tympanic dexamethasone injection (ITD) could serve as a first-line intra-tympanic (IT) treatment for Meniere's disease (MD), regardless of hearing level. Even if the response to initial ITD course was unsatisfactory, a repeated course may be beneficial with some patients. OBJECTIVES:This study examine...

journal_title：Acta oto-laryngologica

authors： Leng Y,Liu B,Zhou R,Liu J,Liu D,Zhang SL,Kong WJ

更新日期：2017-02-01 00:00:00

abstract：CONCLUSIONS:Sensorineural hearing loss must be considered within the clinical picture of systemic lupus erythematosus. The results confirm the usefulness of extended high-frequency audiometry in the audiologic testing of these patients, enabling the possibility of modifying or applying a preventive treatment for a poss...

journal_title：Acta oto-laryngologica

authors： Lasso de la Vega M,Villarreal IM,López Moya J,García-Berrocal JR

更新日期：2017-02-01 00:00:00

abstract：CONCLUSIONS:The distortion product otoacoustic emission (DPOAE) amplitudes in diabetics were significantly lower than those in controls when pure tone audiometry (PTA) was within normal limits, implying cochlear function impairment in the early stage of diabetes mellitus. Retrocochlear damage was suggested by elongated...

journal_title：Acta oto-laryngologica

authors： Hao J,Fu X,Zhang C,Zhang X,Zhao S,Li Y

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Benign paroxysmal positional vertigo (BPPV) is the most common type of peripheral vertigo. This study aimed to evaluate the effects of the Semont maneuver (SM) for BPPV treatment, compared with other methods. METHODS:Studies were selected in relevant databases under pre-defined criteria up to June 2015. The...

journal_title：Acta oto-laryngologica

authors： Zhang X,Qian X,Lu L,Chen J,Liu J,Lin C,Gao X

更新日期：2017-01-01 00:00:00

abstract：CONCLUSION:From aspect of fluid dynamics, expanding patients' nasopharyngeal coronal-sectional area to 48.3-54.7% of normal area will bring the airflow velocity back to normal in adenoidal hypertrophy children. It might provide a suggestion for adenoidectomy range selection and whether total resection is necessary. OB...

journal_title：Acta oto-laryngologica

authors： Hu C,Han D,Zhou B,Zhang L,Li Y,Zang H,Li L

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. METHODS:Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese mu...

journal_title：Acta oto-laryngologica

authors： Okada M,Hato N,Nishio SY,Kitoh R,Ogawa K,Kanzaki S,Sone M,Fukuda S,Hara A,Ikezono T,Ishikawa K,Iwasaki S,Kaga K,Kakehata S,Matsubara A,Matsunaga T,Murata T,Naito Y,Nakagawa T,Nishizaki K,Noguchi Y,Sano H,Sato

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To investigate the positive rate for the Cochlin tomo-protein (CTP: an inner ear-specific protein) detection test among patients with inner ear-related clinical manifestations and evaluate the clinical characteristics of definite perilymphatic fistula (PLF). METHODS:We have performed an ELISA-based CTP detec...

journal_title：Acta oto-laryngologica

authors： Matsuda H,Sakamoto K,Matsumura T,Saito S,Shindo S,Fukushima K,Nishio SY,Kitoh R,Shibasaki O,Ito A,Araki R,Usami SI,Suzuki M,Ogawa K,Hasegawa T,Hagiwara Y,Kase Y,Ikezono T

更新日期：2017-01-01 00:00:00

abstract：CONCLUSIONS:Patients with sudden hearing loss and dizziness after barotrauma should be suspected of barotraumatic perilymph fistula (PLF). Early surgical repair of PLF showed better hearing outcomes. Therefore, diagnostic criteria should help surgical indications of barotraumatic PLF. OBJECTIVES:The aim of this study ...

journal_title：Acta oto-laryngologica

authors： Choi JE,Moon IJ,Kim H,Lee K,Cho YS,Chung WH

更新日期：2017-01-01 00:00:00